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KMID : 0376219870240020217
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Chonnam Medical Journal
1987 Volume.24 No. 2 p.217 ~ p.235
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Fine Structure of the Mesangial Cells in the Renal Glomeruli of the Turtle(Amyda japonica)
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崔在權/Choi, Jae Kwon
金裁弘/朴成植/金伯潤/Kim, Jay Hong/Park, Sung Sik/Kim, Baik Yoon
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Abstract
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Some of the controversy about the existence of the mesangial region of renal glomeruli in mammalian and some other species have been clarified. However, no detailed study on the mesangial cells of the turtle kidney has been reported. The purpose of this study is to clarify the fine structures of the mesangial cells in the renal glomeruli and their relationships to the other cellular components in the mesangium and the juxtaglomerular(JG) apparatus.
Extraglomerular mesangial cells in the JG region had bundles of fine filaments and dense patches within the cytoplasm and along the cell membrane, moderate to well developed Golgi apparatus, dense granules, and glycogen particles. These cells had many processes which often made close contact to the adjacent mesangial cells, to the JG cells and in rare instanes to the distal tubule cells.
Intraglomerular mesangial cells were characterized by having indented nucleus, many cytoplasmic processes, well developed Golgi apparatus, few mitochondria, dense homogenous granules, moderate amount of granular endoplasmic reticulum and relatively abundant glycogen particles. Surrounding these cells was -filam￢entous dense matrix consisting mainly of fine filaments and few occasional collagen fibers. The mesangial cell processes were approximated to base of the endothelial cells without intervening basal lamina and often formed junctions with the endothe￢lial cells. Junctions were also noted between adjacent mesangial cells. Thus, no true basal lamina separated mesangial cells from glomerular endothelial cells. No processes of the mesangial cells were found to be protruded into the capillary lumen, and found beyond the basal lamina of the glomerular epithelium.
Ferritin injected to the jugular vein was taken up by intraglomerular mesangial cells and endothelial cells, and accumulated in the vacuolar structures of both cells.
From these results it is suggested that fine morphology and phagocytotic activity of the mesangial cells of the turtle are generally similar to those of mammalian species, and structural association of mesangial cells with various components in the glomeruli and JG region is significant in rapid and direct transmission of the information regarding the changes in the composition or volume of fluid from one region to the other in the glomeruli and may thereby modulate the renal function through changes in renin secretion, glomerular filtration or tubular reabsorption.
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KEYWORD
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